Tsunade

Tsunade is a descendant of the Senju and Uzumaki Clan and is one of Konohagakure's Sannin. She is famed as the world's strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years.

Tsunade was very willing to believe in the attainability of dreams while her little brother Nawaki and her lover Dan were still alive, and that by supporting and encouraging those dreams, she might be able to help achieve them. When both died gruesomely shortly after receiving her support, Tsunade lost faith in the idea of dreaming for anything, believing that the mere pursuit of it would be doomed from the outset and retiring from the life of a ninja with the intention to spend the rest of her life away from her village in the company of her disciple Shizune, Dan's own niece. Tsunade becomes especially critical of those wanting to be Hokage, as both Dan and Nawaki died trying to attain the title and the past Hokage (including her grandfather Hashirama, her great-uncle Tobirama, and her former teacher Hiruzen) have all died prematurely and, as Tsunade argues, pointlessly because they held the position; she concludes that to be Hokage is a fool's job. Tsunade is forced to reconsider her cynicism upon meeting Naruto Uzumaki, who demonstrates two things to her: just because a goal seems impossible does not mean it actually is, as Naruto is able to master the Rasengan unprecedentedly quickly despite seemingly lacking any natural talent; and just because the dreamer dies does not mean the dream itself does, as Nawaki and Dan's desire to become Hokage lives on in Naruto. Because Naruto is so very much an exception to how she thought the world worked, Tsunade puts her faith in dreams once again, a desire so strong that she overcomes her fear of blood.[16] She becomes Hokage herself, partly so that she can live Nawaki and Dan's dream for them, but also so that she can pave the way for Naruto inevitably holding the title. Becoming close to Naruto, he became the only person she allowed to refer to her as "Grandma", knowing it was out of affection. Later, when Tsunade is approached by Sakura Haruno, who asks to be her disciple and be taught medical ninjutsu, Tsunade heartily agrees not only because she senses Sakura's potential but because she realizes Sakura has something she wants to protect (Sasuke Uchiha and Naruto himself) just like she wanted to protect Nawaki and Dan. As a result, Tsunade spends the next years juggling between her roles as a village leader and as a mentor with great devotion, despite the constant stress the former position puts on her.

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